The National Rugby League has become embroiled in another sex scandal following allegations that a young woman was drugged and raped at a Sydney unit.

Wests Tigers rugby league club says it is working with police after a 26-year-old woman said she may have been sexually assaulted on Monday at a unit in Five Dock, in Sydney's inner-west.

A crime scene has been established at the unit, which is believed to be the residence of a Wests Tigers player.

Police would not confirm reports the alleged incident involved first grade NRL players.

Macquarie Radio presenter Ray Hadley said the allegation involved up to four Wests Tigers players during the team's end-of-season "Mad Monday" celebrations.

"The allegation may be that a date rape drug may have been used ... and that's why the suggestion is from the alleged victim that she may have been raped," Mr Hadley said.

"My information is she was known to the players through circumstances which will become obvious later on."

Tigers chief executive Steve Noyce said the club had not been informed of any specific allegations against any players.

"We have been made aware of an allegation that a woman may have been sexually assaulted early Monday morning at a place where both Wests Tigers players and others were present," Mr Noyce said in statement.

"We are not aware at this stage of any specific allegation against a Wests Tigers player and the club is very keen to work with the police to establish what may or may not have taken place."

Wests Tigers' season ended on Sunday with a 52-18 win over South Sydney at Leichhardt Oval.

"I'm aware that after our last game against South Sydney obviously the players went back and would have had drinks to complete the season but where and when they went after that I'm not 100 per cent sure," Mr Noyce told Macquarie Radio.

"As a club we don't condone Mad Monday celebrations in any way, shape or form."

A police spokeswoman said detectives from the Child Protection and Sex Crimes Squad and Burwood Local Area Command were investigating the allegation.

"At 10.40am on Monday, a 26-year-old female attended Parramatta police station and alleged that she may have been sexually assaulted at a home unit in Five Dock," she said.

The latest claims follow several high-profile incidents involving NRL players in recent years.

In February last year Newcastle Knights players reportedly went on a drunken rampage through a student dormitory at Charles Sturt University in Bathurst, allegedly indecently assaulting one female student.

In February 2004 Bulldogs player were accused of raping a 20-year-old woman following a pre-season trial win over Canberra in Coffs Harbour and three months later St George Illawarra centre Mark Gasnier was expelled from the NSW State of Origin team after making an obscene phone call to a woman during a Blues bonding session.

In March 2003 another woman accused Bulldogs players of a sexual assault, claiming she had consensual intercourse with one player at a Coffs Harbour hotel but was awoken having sex with a different player, while a third player watched.

The code has also been plagued this season with Cronulla hooker Tevita Latu sacked for punching a woman in the face. Parramatta rookie of the year Jarryd Hayne was fined $1,000 for biting a woman on the arm at a nightclub while Brisbane halfback Brett Seymour had his contract torn up after allegations he head-butted a woman on the dance floor at a Brisbane pub, though no charges were laid.

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