Kiwi international Setaimata Sa has been ruled out of the Sydney Roosters side for Friday night's NRL clash with Penrith at Sydney Football Stadium due to a neck injury.

Sa is expected to miss just the one week with the injury, with Brent Grose to join the Roosters bench and NSW forward Anthony Tupou to now start the game.

Coach Brad Fittler meanwhile has loaded his starting side with Queensland's Nate Myles given a starting role ahead of Mark O'Meley ensuring all four of the Roosters Origin forwards will start the game.

Penrith have made their own changes with winger Jarrod Sammut dropped to NSW Cup this weekend and Tim Grant added to the interchange with a reshuffle of the starting side.

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