Wests Tigers have lost fullback Brett Hodgson and winger Beau Ryan for Saturday night's NRL match against Penrith at CUA Stadium.

Hodgson failed to pass a fitness test on his injured calf muscle and will be replaced at the back for the second week in a row by young utility Tim Moltzen.

Ryan has an ankle injury with Tigers coach Tim Sheens to wait until an hour before kick-off to decide on his replacement.

Amongst those in line for a call-up is giant Toyota Cup flyer Peni Tagive who made his NRL debut in round one before losing his place in the top grade due to injury.

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