Penrith NRL hooker Masada Iosefa has been charged with affray following a brawl outside a Sydney hotel.

Iosefa was one of two men arrested after a fight erupted between a group of men and security guards outside the Mean Fiddler Hotel in Rouse Hill on Saturday night.

Penrith chief executive Mick Leary said the 21-year-old hooker would defend charges of affray and failing to quit licensed premises.

Leary confirmed that Panthers star and NSW Origin hopeful Michael Jennings was also present at the incident but said the young centre was not taken into police custody as had been reported.

"I have spoken to both players this morning in relation to last night's incident and both have been extremely cooperative and are available and willing to assist police with their inquiries," he said in a statement on Sunday.

"The player, Masada Iosefa has subsequently been charged with affray and failing to quit licensed premises.

"Masada will be defending the charges.

"The club is treating the matter very seriously and is continuing inquiries. We respect the matter is now in the hands of the police and are unable to make any further comments.

"Regarding further action from the club we are not in a position at this stage to determine disciplinary action against Masada Iosefa. That will be determined at an appropriate time."

The NRL on Sunday said it was monitoring the situation and would wait on a report from the Panthers before commenting.

It is believed a number of Panthers players were at the hotel to celebrate Jennings' 21st birthday which is on Monday.

According to a police statement issued late Saturday night, a group of men were asked to leave a licensed premises on Windsor Road at Rouse Hill because of intoxication.

The group left but about 20 minutes they allegedly returned to the scene and a brawl erupted between the group and a number of security guards at the premises.

Police arrived while the altercation was occurring and arrested a 21-year-old Mt Druitt man.

A second man, a 21-year-old from Dharruk, allegedly attempted to flee the scene when approached by police but was subdued with capsicum spray.

Both men were arrested and taken to Castle Hill police station where they were charged.

Both have been bailed to appear at Hornsby Local Court on May 5.

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