Gold Coast captain Scott Prince will reach a destination he once doubted he would get anywhere near in Friday night's NRL clash with South Sydney.

Prince will play his 250th game, a prospect which looked unlikely after he suffered two broken legs when he was with Brisbane between 2001-03.

"It's a milestone that I never thought I'd reach in the early part of my career," Prince admitted on Thursday.

"Especially (during) my time at the Broncos, I spent a lot of time on the sidelines through injury.

"The one thing that I learnt was never take anything for granted, to play each game as it comes because it could be your last."

The 31-year-old, who began his career at North Queensland in 1998, found himself at a struggling Wests Tigers outfit in 2004 after he was cut loose by the Broncos.

By the end of 2005 he was a Tigers legend after he played a massive role in delivering the joint venture club a fairytale first premiership.

On Friday night the popular playmaker goes head-to-head with young Rabbitohs halfback Chris Sandow, a player some believe could one day emulate Prince as a Queensland State of Origin representative.

But it was the master showing the apprentice the way the last time the sides met at ANZ Stadium, Prince slotting an 81st-minute field goal to secure a 19-18 golden point victory.

Both sides will assess their battered Origin contingent on match day ahead of the crucial showdown.

The Rabbitohs are expecting centre Greg Inglis and backrower Dave Taylor to back up after both were part of the Queensland side that lost 18-8 to NSW on Wednesday night.

Inglis suffered a knock to his shoulder in the Origin match, but Maroons coach Mal Meninga described it as a "burner" and said there was no serious damage.

The Titans were linking with Origin forwards Greg Bird and Ashley Harrison when they arrived in Sydney on Thursday night, officials aware both had taken plenty of bumps and bruises.

The two sides are desperate to stay in touch with the top eight with Souths sitting four points adrift and the Titans six.

Gold Coast are looking to build some momentum and post back-to-back wins for the first time in 2011 after last week's morale boosting 28-14 away win over depleted premiers St George Illawarra.

"We had a really good win last week which was a shot of confidence that was certainly needed," Prince said.

"All the boys are buzzing now and we're working really hard to build on that."

The Rabbitohs haven't beaten Gold Coast in three years, the Titans holding a 4-2 record against the foundation club.

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