For Hawthorn, it was a big win at a big cost.

The Hawks' inspiring 30-point come-from-behind AFL victory over St Kilda looks to have lengthened their long-term injury list, with key defender Stephen Gilham facing 12 months out after seriously damaging his knee.

And ruckman David Hale also injured his knee in the second term of Sunday's 14.15 (99) to 10.9 (69) win.

Scans on Monday will determine how long he is sidelined.

But Gilham looks set to require surgery and lengthy rehabilitation after buckling his knee early in the first quarter.

Coach Alastair Clarkson says the likelihood is Gilham will be sidelined for a year.

The injury leaves the Hawks without two tall defenders for the remainder of the season after Ben Stratton's knee injury earlier this year.

Hale's injury also causes problems in the Hawks' ruck division, with No.1 Brent Renouf also sidelined with a minor hamstring strain.

Hawthorn were forced to send forward Jarryd Roughead to pinch-hit in the ruck against the Saints, and he produced an outstanding performance.

"We've been using him in that type of role, but I don't think anyone anticipated he'd have to shoulder the responsibility. It was such a lion-hearted effort from him today," Clarkson said.

"Roughy was first class. We've got some lads that can come in and replace those boys. One door closes and another one opens."

Young defender Ryan Schoenmakers, who has recovered from early-season injury, looks the most likely replacement for Gilham.

And Hale's injury could open the door for luckless Hawk Max Bailey, who is coming back from a third knee reconstruction, to get another shot at the AFL.

Also in doubt for the Hawks' away clash with Sydney next weekend is defender Paul Puopolo.

The second-gamer bravely played through Sunday's game, despite a heavy knock to his shin in the third quarter, to help his already-undermanned side.

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