Newcastle Knights chief executive Steve Burraston expects Chris Houston to officially resign from the NRL club on Wednesday afternoon.

Houston was charged with three counts of supplying ecstasy and one count of supplying cocaine on Monday and was stood down indefinitely by the club.

Burraston says Houston offered his resignation this morning and the board would accept it.

"Chris Houston has indicated to me today that he will be resigning from the Newcastle Knights," Burraston told AAP.

"I expect that will happen today.

"I've indicated to Chris that I will accept his resignation.

"It is important that we give him time to fight these alleged charges and obviously he wouldn't be able to get his mind around football.

"We expect that (his resignation) sometime this afternoon, that we will get notification from Chris of his resignation and the club has indicated it will accept it."

The former St George Illawarra forward's impending exit comes less than three months after Houston's former Knights teammate and flatmate Danny Wicks was charged with supply and possession of a prohibited substance.

Wicks left the club in December after he was released on bail and will appear in court again on March 31.

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