Wests Tigers will hand an NRL debut to 20-year-old second-rower Simon Dwyer against North Queensland at Leichhardt Oval on Sunday.

The 192cm-tall Dwyer, is called up from the club's Toyota Cup side and takes his place on the interchange bench in a game the Tigers have to win to keep alive their hopes of reaching the finals.

"He is a big, strong backrower, who plays on the right edge and hits a good line, has a good offload and we think he has a big future," said Tigers assistant coach Royce Simmons.

The Tigers will meet an in-form Cowboys side sitting fifth on the ladder, boosted by the return of Johnathan Thurston after State of Origin duty on Wednesday.

However the visitors will be without NSW second-rower Luke O'Donnell (knee) and hooker Aaron Payne (shoulder) who are both sidelined through injury.

Meanwhile Brisbane coach Ivan Henjak has named 20-year-old Alex Glenn in his side to face South Sydney at Suncorp Stadium on Friday.

The match is the first of two games at the venue, in an NRL double header also featuring the Bulldogs and Gold Coast Titans.

Glenn will fill in for injured Queensland and Australia winger Israel Folau who is sidelined with a broken ankle.

Ben Te'o returns to the Broncos bench, after a two-week suspension.

Souths are unchanged from last week's morale-boosting win over Penrith, but name Origin stars Craig Wing and Michael Crocker on an extended interchange bench.

The Titans welcome back Preston Campbell for their trip to Brisbane to face the Bulldogs, who are officially the home side after moving the fixture from ANZ Stadium.

Campbell missed Monday's win over Parramatta with the flu and is joined back in the side by Queensland forward Ashley Harrison.

The Bulldogs are boosted by the return of Origin stars Michael Ennis, Brett Kimmorley and Josh Morris, but are still without the suspended Bryson Goodwin and injured forward Ben Hannant (knee).

The Warriors, whose season hit a new low when they were beaten 18-14 at home to a Bulldogs side missing eight key players last week, have called up young five-eighth Isaac John for his first grade debut against Sydney Roosters on Sunday.

The 20-year-old is the seventh player from the club's junior ranks to make his debut in the last two years, and will replace Lance Hohaia who is dropped to the bench.

The Roosters are without the suspended Nate Myles but welcome back Sia Soliola, who is named on an extended interchange bench after a hamstring injury that had sidelined him for the last two games.

In the final game of the round on Monday, Nathan Hindmarsh will become only the third Parramatta player to make 250 appearances for the club when he runs out against Melbourne at Parramatta Stadium.

Jarryd Hayne will play at fullback for the Eels after State of Origin, with Luke Burt moving to the wing and Krisnan Inu back to the centres.

The Storm have named former Parramatta halfback Brett Finch in their side, but will make a decision on his fitness on the day of the game after he sustained a partially collapsed lung in the round 17 win over Newcastle.

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