Instead of making his AFL debut this Sunday, North Melbourne midfielder Liam Anthony is nursing stress fractures in his foot.

Anthony pulled up sore on Thursday night at training and scans confirmed the injury, putting him out of action for four to six weeks.

The 21-year-old had shown strong pre-season form after the Kangaroos recruited him up with their third-round pick in last November's national draft.

Andrew Swallow has taken his place in the side, while Jack Ziebell will play his first senior game against Melbourne at the MCG.

Ziebell was North's top pick at No.9 in last year's draft.

The Demons will have four first-gamers - Jake Spencer, Jamie Bennell, Kyle Cheney and Neville Jetta.

The Western Bulldogs will have no newcomers for the Sunday twilight game against Fremantle at Subiaco.

But Brownlow medallist Adam Cooney and forward Robert Murphy were picked after interrupted pre-seasons and defender Tom Williams is an emergency.

Last year's No.3 draft pick, Stephen Hill, and Nick Suban will make their AFL debuts after they made Fremantle's final 22.

Josh Carr returns to Port Adelaide's side for their home match on Sunday afternoon against Essendon.

He is their only "new" player, having returned to the Power after four seasons at Fremantle.

Key defender Michael Hurley, Essendon's top draft selection last November at No.5, is set for his first senior game.

The Bombers have also picked former Adelaide utility Hayden Skipworth.

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