If only the physician could heal thyself.

John Roe, qualified doctor and Queensland's most capped No.8, has announced his retirement from the game, citing a shoulder injury that just wouldn't mend.

The 31-year-old former Reds captain and Wallaby had a reconstruction in the 2007 off-season and missed the last three games of the 2008 competition when a further operation was required on the troublesome left shoulder.

He told teammates that the injury was not responding to treatment as well as he'd hoped, prompting him to give away the game.

"I'd love nothing more than to be part of this team again next year, but not at the risk of being a passenger for all or part of the season.

"It's better for everyone if I make the call now," said Roe, who has played 107 matches for Queensland since making his debut in 1999.

"When I first started playing rugby I never thought I would represent the Reds and to have played over 100 games is an absolute honour."

Roe became captain of the Reds midway through 2005 and led the side through the difficult 2006 and 2007 seasons before making way for Sam Cordingley to lead the team midway through 2008.

He played 19 Tests for the Wallabies after making his debut during the 2003 Rugby World Cup.

Roe scored 105 points for his state and 10 Test points.

He will now concentrate on a career in medicine.

Reds coach Phil Mooney paid tribute to Roe's contribution to Australian and Queensland rugby, saying his loyalty, courage and determination was an example to all.

"John Roe is a true Red who typified the values and character that we prize and want younger players to aspire to," Mooney said.

"It's typical of Roey that he's putting the team first with this decision.

"He's always done that in his career and it hasn't always been an easy ride for him. He played through a lot of pain last season rather than let the team down.

"John ranks right up there with the true greats of Queensland rugby and will always be honoured and remembered for that."

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