South Sydney's jubilation has quickly become a reality check with star five-eighth John Sutton and lock Ben Lowe both ruled out for the rest of the injury-ravaged NRL club's season.

The Rabbitohs pulled off a miraculous last-second 34-30 golden point extra time win over the Wests Tigers on Saturday night, one of the famous club's gutsiest considering 12 first-graders were on the sidelines.

Lowe was among them, a late withdrawal after fracturing his foot in a freak training accident on Friday, bringing his impressive season to an end.

Sutton dislocated his right shoulder in the first period of extra time and left the field in agony.

It's the same shoulder he suffered an identical injury to in 2007, when he required surgery.

The Rabbitohs linchpin will have an MRI scan on Sunday but medical staff are resigned to him having another operation.

Sutton also copped a knock on his left shoulder which he played through but that injury is not considered serious.

Down nine players when their side was named last week, Souths lost both centres as well as Lowe before kick-off at ANZ Stadium.

Beau Champion succumbed to a cork above his knee in the side's final training session while Colin Best is on a drip in hospital with a systemic blood infection suffered after he accidentally cut himself.

Best is expected to leave hospital on Monday and the Rabbitohs are hopeful both he and Champion will play against Melbourne at AAMI Park next Sunday.

Also back will be suspended English star Sam Burgess, utility Luke Capewell (knee) and possibly veteran forward Michael Crocker (quad).

The Rabbitohs remain two points outside the top eight after debutant Dylan Farrell's last-second golden-point try to down the Tigers.

But the loss of their main playmaker in Sutton and an injury list which will still include Lowe, Luke Stuart (hand), Scott Geddes (knee), Dave Taylor (collarbone) and Beau Falloon (arm) will make it tough for the club to make the play-offs.

Apart from the thrilling win, the bright spot for Souths was the stunning debut of Farrell, who scored a classy hat-trick on debut.

"The first one, (halfback) Chrissy (Sandow) just gave me some early ball and I just had a go, threw a dummy and luckily got over," the 19-year-old Nowra product said of a strong individual effort.

"The second one (a kick) just popped up into my hand, I don't even know how that happened."

The five-eighth turned centre said belief had been the key to the win.

"Langy (coach John Lang) said we need to get some more belief in this club, believe in each other," he said.

"He doesn't want to hear about who's out, the people that are playing just need to step up and that's what we did."

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