St Kilda produced one of their great AFL wins of recent times with a 28-point victory over Collingwood on Friday night.

Riewoldt sustained the injury just before half-time when he leapt for a mark on the lead and immediately grabbed at his right hamstring when he hit the ground, before he hobbled off for treatment.

The Seven Network reported the All-Australian skipper had torn the hamstring tendon from the bone, which would require a lengthy stint on the sidelines.

The Saints then lost another player, as defender Sam Fisher was carried off midway through the third quarter after he was knocked out in a heavy collision with Magpie Leon Davis as both players went for the ball.

But despite playing two men down the Saints kicked the only two goals of the third quarter and the only four of the last and won 10.9 (69) to 4.17 (41).

St Kilda's win - their fourth in succession over Collingwood - kept them on top of the ladder at the start of round three and proved there is plenty of fight in a side stocked with talent.

Brendon Goddard kicked two goals for the Saints, Nick Dal Santo set up the first two of the last quarter and Fisher and Lenny Hayes typified St Kilda's courage by returning to the field.

Fisher returned midway through the last quarter, while Hayes starred early and then played out the game with a bandaged face after he was left bleeding when he ran into teammate Steven King.

In a drama-filled match, a scuffle broke out before the opening bounce and another occurred at quarter-time.

Spot fires continued in the second quarter between St Kilda goalsneak Stephen Milne and opponent Harry O'Brien, and Milne and former teammate Luke Ball - the Collingwood midfielder playing his old side for the first time in a premiership game.

But St Kilda retained their composure, and fought back from a three-point deficit at half-time.

Dayne Beams put Collingwood in front with the last goal of the first half, as Riewoldt left the field, but from that point the Saints dominated.

Milne set his side alight with a dribbled goal at the start of the third quarter, but the Magpies literally kicked themselves out of the game.

Travis Cloke had a shot immediately after Fisher was carried off but missed from 40 metres, and the Magpies' kicking plummeted.

They scored just six behinds in the third term and their second-half return was a dismal 0.9.

Riewoldt had been kept quiet in the first half by opponent Simon Prestigiacomo, and also suffered an ankle injury in the second quarter, but returned to the field after five minutes of treatment.

His hamstring injury will stretch the Saints given forward Justin Koschitzke still has one more game to serve of his suspension.

Riewoldt was non-committal after the game and said he would wait for assessment before knowing the severity of his injury.

St Kilda coach Ross Lyon was also unsure how bad his star's injury was, but was hopeful it was not serious.

The Saints are likely to send Riewoldt for scans on Saturday.

"We're going to investigate it," Lyon said.

"Do you think if I thought it was off the bone I'd have half a smile on my face now?

"He's a special player, all the St Kilda people don't want to see him get hurt."

Lyon said it was brave for Fisher and Hayes to return and commended his side for its win.

"I thought it was a magnificent effort. Everything was thrown at us and we responded in kind, like good teams do," he said.

Lyon said St Kilda were also looking into what sparked the scuffle at quarter-time, as Collingwood coach Mick Malthouse was nearby Milne when words were exchanged.

But Malthouse said he was only telling his players not to get involved in any scuffle.

Malthouse said the Magpies were not up to mark, and blamed their bad kicking for the defeat.

"We were just not good enough," he said.

"It's the old cliche, a lot of things might change in life but certainly one doesn't - bad kicking is bad footy, if you don't kick enough goals you don't win games of football."

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