Essendon captain Matthew Lloyd expects to miss up to five AFL matches with a hamstring injury.

While internal bleeding has prevented scans from fully diagnosing the extent of the injury, Lloyd said he was sure he would miss 3-5 matches.

"Up to five weeks at the moment, but I suppose when the bleeding ... subsides I'll get a better indication," Lloyd told the Seven Network.

"Three (weeks) at the least I think, just the way I'm feeling."

The club on Monday expressed hope its skipper might be available for next Tuesday's much-anticipated Anzac Day clash with Collingwood, the first match of the season at the revamped MCG.

Lloyd will be treated in a hyperbaric chamber daily for the next fortnight.

"It's a bit of a bad bleeder, so I've got a corky and strained or torn the hamstring at the same time," he said.

Lloyd appeared to strain his left hamstring when lunging for a mark in Sunday's match against the Western Bulldogs, then he sustained a corked leg when opponent Brian Harris landed heavily on him later in the game.

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